Liu, C., Cozens, C., Jaziri, F.,  Rozenski, J., Maréchal, A., Dumbre, S.G., Pezo, V., Marliere, P., Pinheiro, V.B.*, Groaz, E., and Herdewijn, P.* (2018) Phosphonomethyl Oligonucleotides as Backbone Modified Artificial Genetic PolymersJournal of the American Chemical Society, 60(4), 393 *corresponding authors.

Cozens, C. and Pinheiro, V.B. (2018) Darwin Assembly: fast, efficient, multi-site bespoke mutagenesis. Nucleic Acid Research, 46(8), e51


Torres, L.*, Krüger, A., Csibra, E., Gianni, E. and Pinheiro, V.B.* (2016) Synthetic Biology approaches to biological containment: pre-emptively tackling potential risks. Essays in Biochemistry, 60(4), 393 *corresponding authors.

Tizei, P.A., Csibra, E., Torres, L. and Pinheiro, V.B. (2016) Selection platforms for directed evolution in Synthetic Biology. Biochemical Society Transactions, 44(4), 1165


Bande, O., Abu El Asrar, R., Braddick, D., Dumbre, S., Pezo, V., Schepers, G., Pinheiro, V.B., Lescrinier, E., Holliger, P., Marlière, P. and Herdewijn, P. (2015) Isoguanine and 5-Methyl-Isocytosine Bases, In Vitro and In Vivo. Chemistry – A European Journal 21,  5009


Taylor, A.I., Pinheiro, V.B., Smola, M.J., Morgunov, A.S., Peak-Chew, S., Cozens, C., Weeks, K.M., Herdewijn, P. and Holliger, P. (2014) Catalysts from synthetic genetic polymers, Nature518, 427

Pinheiro, V.B.*, Arangundy-Franklin, S., and Holliger, P. (2014) Compartmentalized self-tagging for in vitro directed evolution of XNA polymerases, Current Protocols in Nucleic Acid Chemistry, UNIT 9.9  *corresponding author.

Pinheiro, V.B. and Holliger, P. (2014) Towards XNA nanotechnology: new materials from synthetic genetic polymers, Trends in Biotechnology32(6), 321


Wynne, S.A., Pinheiro, V.B., Holliger, P. and Leslie, A.G.W. (2013) Structures of an Apo and a Binary Complex of an Evolved Archeal B Family DNA Polymerase Capable of Synthesising Highly Cy-Dye Labelled DNA. PLoS ONE, 8(8): e70892

Pinheiro, V.B.*, Loakes, D. and Holliger, P. (2013) Synthetic polymers and their potential as genetic materials. Bioessays, 35, 113 *corresponding author.

2012 and earlier

Pinheiro, V.B. and Holliger, P. (2012) The XNA world: Progress towards replication and evolution of synthetic genetic polymers. Current Opinion in Chemical Biology, 16, 245

Cozens, C., Pinheiro, V.B., Vaisman, A., Woodgate, R. and Holliger, P. (2012) A short adaptive path from DNA to RNA polymerases. PNAS, 109, 8067

Pinheiro, V.B., Taylor A.I., Cozens, C., Abramov, M., Renders, M., Zhang, S., Chaput, J., Wengel, J., Peak-Chew, S-Y., McLaughlin, S.H., Herdewijn, P. and Holliger, P. (2012) Synthetic genetic polymers capable of heredity and evolution. Science, 336, 341

Pinheiro, V.B., Ong, J.L. and Holliger, P. (2012) Polymerase engineering: From PCR and sequencing to synthetic biology. Protein Engineering Handbook, volume III, chapter 12. Edited by Stefan Lutz. Wiley-VCH, Weinheim. ISBN: 978-3-527-33123-9

Attwater, J., Wochner, A., Pinheiro, V.B., Coulson, A. and Holliger, P. (2010) Ice as a protocellular medium for RNA replication. Nature Communications, 1, 1

Loakes, D., Gallego, J., Pinheiro, V.B., Kool, E.T. and Holliger, P. (2010) Evolving a polymerase for hydrophobic base analogues. Journal of the American Chemical Society, 131, 14827

Pinheiro, V.B. and Ellar, D.J. (2007) Expression and insecticidal activity of Yersinia pseudotuberculosis and Photorhabdus luminescens toxin complex proteins. Cellular Microbiology, 9, 2372

Pinheiro, V.B. and Ellar, D.J. (2006) How to kill a mocking bug? Cellular Microbiology, 8, 545

Vitor Pinheiro

Vitor Pinheiro